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Released from necrotic cells and subsequently activates IL-1R1 present at the surface of mesothelial cells. This was proposed to be the prime event inducing neutrophil infiltration and peritoneal inflammation rather than the HMGB1 pathway.152,153 This proinflammatory role of IL-1 was recently confirmed in a mouse model of acute colon inflammation (dextran sodium sulfate-induced colitis), where epi
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Streammitogen-activated protein kinase (MAPK) signaling and NFB activation (Figure 2).149,150 Thus, IL-1 activates neighboring fibroblasts or epithelial cells, further triggering the release of chemokines that leads immune cells, preferentially neutrophils,151 to infiltrate and enhance local inflammation. IL-1 in sterile inflammation: from acute to chronic disease As previously mentioned, pIL-1 is
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Streammitogen-activated protein kinase (MAPK) signaling and NFB activation (Figure 2).149,150 Thus, IL-1 activates neighboring fibroblasts or epithelial cells, further triggering the release of chemokines that leads immune cells, preferentially neutrophils,151 to infiltrate and enhance local inflammation. IL-1 in sterile inflammation: from acute to chronic disease As previously mentioned, pIL-1 is
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Ulation of host mRNAs on polyribosomes during obligate pathogen-plant interactions. Mol. Biosyst. 8: 2153-2165. Monzingo, A.F., dhaliwal, S., dutt-Chaudhuri, A., Lyon, A., Sadow, J.H., Hoffman, d.W., Robertus, J.d., and Browning, K.S. (2007). The structure of eukaryotic translation initiation factor-4E from wheat reveals a novel disulfide bond. Plant Physiol. 143: 1504-1518. Moreau, M., Azzopardi,
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Released from necrotic cells and subsequently activates IL-1R1 present at the surface of mesothelial cells. This was proposed to be the prime event inducing neutrophil infiltration and peritoneal inflammation rather than the HMGB1 pathway.152,153 This proinflammatory role of IL-1 was recently confirmed in a mouse model of acute colon inflammation (dextran sodium sulfate-induced colitis), where epi
1
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