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Ling pIL-1 processing by calpain and the release of mature IL-1. However, Gross et al.137 showed that caspase-1 dependency for IL-1 secretion can differ depending on the stimulus and the targeted inflammasomes and does not seem to require the protease activity of caspase-1. IL-1 secretion may therefore rely on redundant parallel pathways. In fact, elevated intracellular Ca2+ triggers IL-1 secretio
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O moderate its negative effects will be crucial for the efficient treatment of many patients. INTERLEUKIN-1a The IL-1 family of proteins contains 11 members. The beststudied family members are IL-1 and IL-1. Both are highly similar in structure and bind to the same cell membrane receptor, IL-1R. Interestingly, IL-1 receptor antagonist (IL-1Ra) is a naturally expressed member of the IL-1 family tha
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O moderate its negative effects will be crucial for the efficient treatment of many patients. INTERLEUKIN-1a The IL-1 family of proteins contains 11 members. The beststudied family members are IL-1 and IL-1. Both are highly similar in structure and bind to the same cell membrane receptor, IL-1R. Interestingly, IL-1 receptor antagonist (IL-1Ra) is a naturally expressed member of the IL-1 family tha
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