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Dependent secretion mechanism.139,140 Further differentiating itself from IL-1 and HMGB1, IL-1 activation and secretion is inhibited by autophagy. Indeed, in the context of Mycobacterium tuberculosis infection, ATG5-dependent autophagy was shown to block both the calpain-dependent activation of IL-1 and its secretion, thereby limiting lung inflammation and tissue damage.141 Another regulatory mech
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Streammitogen-activated protein kinase (MAPK) signaling and NFB activation (Figure 2).149,150 Thus, IL-1 activates neighboring fibroblasts or epithelial cells, further triggering the release of chemokines that leads immune cells, preferentially neutrophils,151 to infiltrate and enhance local inflammation. IL-1 in sterile inflammation: from acute to chronic disease As previously mentioned, pIL-1 is
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Ty and downstream phosphorylation of S6 kinase. Biochimie 88: 11-21. Paik, I., Yang, S., and Choi, G. (2012). Phytochrome regulates translation of mRNA in the cytosol. Proc. Natl. Acad. Sci. U S A 109: 1335-1340. Pajerowska-Mukhtar, K.M., Wang, W., Tada, Y., Oka, N., Tucker, C.L., Fonseca, J.P., and dong, X. (2012). The HSF-like transcription factor TBF1 is a major molecular switch for plant growt
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Ulation of host mRNAs on polyribosomes during obligate pathogen-plant interactions. Mol. Biosyst. 8: 2153-2165. Monzingo, A.F., dhaliwal, S., dutt-Chaudhuri, A., Lyon, A., Sadow, J.H., Hoffman, d.W., Robertus, J.d., and Browning, K.S. (2007). The structure of eukaryotic translation initiation factor-4E from wheat reveals a novel disulfide bond. Plant Physiol. 143: 1504-1518. Moreau, M., Azzopardi,
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